Rider berjuluk X-Fuera itu mencatatkan waktu 1 menit 32.830 detik, unggul lebih cepat dari pebalap Ducati Andrea Iannone.
Posisi ketiga ditempati joki Repsol Honda, Marc Marquez yang menorehkan waktu 1 menit 33.313 detik.
Kabar angin segar juga datang untuk pebalap tim Octo Pramac Yakhnich, Danilo Petrucci, dia kembali mengaspal usai mengalami cedera retak tangan.
Rekan Lorenzo sekaligus rival, Valentino Rossi justru tercecer ke peringkat ke-10 dalam sesi latihan bebas kedua ini.
Berikut hasil catatan waktu latihan bebas kedua (FP 2) GP Perancis:
2. Andrea Iannone ITA Ducati Team (Desmosedici GP) 1m 33.169s +0.339s [20/20] 314km/h
3. Marc Marquez ESP Repsol Honda Team (RC213V) 1m 33.313s +0.483s [19/21] 307km/h
4. Pol Espargaro ESP Monster Yamaha Tech 3 (YZR-M1) 1m 33.406s +0.576s [20/22] 309km/h
5. Andrea Dovizioso ITA Ducati Team (Desmosedici GP) 1m 33.574s +0.744s [21/21] 316km/h
6. Aleix Espargaro ESP Team Suzuki Ecstar (GSX-RR) 1m 33.595s +0.765s [17/18] 304km/h
7. Maverick Viñales ESP Team Suzuki Ecstar (GSX-RR) 1m 33.613s +0.783s [19/20] 307km/h
8. Dani Pedrosa ESP Repsol Honda Team (RC213V) 1m 33.748s +0.918s [8/20] 309km/h
9. Hector Barbera ESP Avintia Racing (Desmosedici GP14.2) 1m 33.951s +1.121s [18/20] 311km/h
10. Valentino Rossi ITA Movistar Yamaha MotoGP (YZR-M1) 1m 33.974s +1.144s [16/19] 306km/h
11. Danilo Petrucci ITA Octo Pramac Yakhnich (Desmosedici GP15) 1m 34.050s +1.220s [17/20] 310km/h
12. Cal Crutchlow GBR LCR Honda (RC213V) 1m 34.053s +1.223s [13/14] 309km/h
13. Scott Redding GBR Octo Pramac Yakhnich (Desmosedici GP15) 1m 34.083s +1.253s [17/17] 310km/h
14. Bradley Smith GBR Monster Yamaha Tech 3 (YZR-M1) 1m 34.306s +1.476s [18/23] 308km/h
15. Loris Baz FRA Avintia Racing (Desmosedici GP14.2) 1m 34.364s +1.534s [15/16] 302km/h
16. Eugene Laverty IRL Aspar MotoGP Team (Desmosedici GP14.2) 1m 34.425s +1.595s [18/19] 309km/h
17. Yonny Hernandez COL Aspar MotoGP Team (Desmosedici GP14.2) 1m 34.531s +1.701s [17/18] 307km/h
18. Jack Miller AUS Estrella Galicia 0,0 Marc VDS (RC213V) 1m 34.656s +1.826s [17/18] 305km/h
19. Stefan Bradl GER Factory Aprilia Gresini (RS-GP) 1m 34.742s +1.912s [17/20] 300km/h
20. Tito Rabat ESP Estrella Galicia 0,0 Marc VDS (RC213V)* 1m 34.789s +1.959s [22/22] 300km/h
21. Alvaro Bautista ESP Factory Aprilia Gresini (RS-GP) 1m 35.089s +2.259s [18/19] 306km/h